HYBRIDIZATION APPROACH TO IDENTIFY SALICYLANILIDES AS INHIBITORS OF TUBULIN POLYMERIZATION AND SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION 3 (STAT3)

The superimposition of the X-ray complexes of cyclohexanediones (i.e., TUB015), described by our research group, and nocodazole, within the colchicine binding site of tubulin provided an almost perfect overlap of both ligands.This structural information led us to propose hybrids of TUB015 and nocodazole using a salicylanilide Diodes core structure.

Abstract High-throughput phenotypic screening is a cornerstone of drug development and the main technical approach for stem cell research.However, simultaneous detection of activated core factors responsible for cell fate determination and accurate assessment of directional cell transition are difficult using conventional screening methods that foc